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From: daemon@ig.UUCP
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Subject: CSLG: COMMENTARY: From Ellis Golub (3)
Message-ID: <4261@ig.ig.com>
Date: Tue, 1-Dec-87 14:41:32 EST
Article-I.D.: ig.4261
Posted: Tue Dec  1 14:41:32 1987
Date-Received: Sat, 5-Dec-87 13:17:45 EST
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From: Sunil Maulik 

         Computer Applications in the Sequencing of Large Genomes


    What will we be searching for in the new, large databases?  One use 
for total genomic DNA will be to locate genomic sequences for isolated 
cDNA. Thus, after sequencing the cDNA for a message of interest, one would 
usually like to obtain the genomic sequence, including the structure of 
the gene and the upstream and downstream regulatory elements. Rather than 
having to fish a genomic clone out of a library, as is the current 
practice, it will be possible to find the gene, along with possible 
pseudogenes, in the database. Indeed, from what is now known, one might 
only need a small amount of cDNA sequence to deduce the entire message 
sequence and genomic structure from the database. In addition, the 
chromosomal location of the gene will also be known, and the possible 
relationship of the gene to genetically mapped heritable diseases will 
also be evident. The rapid availability of such information could well 
justify the difficulty and expense of building the database.

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