Path: utzoo!attcan!utgpu!watmath!uunet!bionet!vax.bio.leeds.ac.uk!ACTN From: ACTN@vax.bio.leeds.ac.uk Newsgroups: bionet.jobs Subject: (none) Message-ID: <2260052E_00100B88.00929681803D3BC0$2_1@UK.AC.LEEDS.BIO.VAX> Date: 17 Aug 89 14:09:18 GMT Sender: daemon@NET.BIO.NET Lines: 27 ASTBURY DEPT OF BIOPHYSICS, UNIVERSITY OF LEEDS SERC CASE Studentship (in collaboration with Hannah Research Laboratory) MOLECULAR RECOGNITION, SPECIFICITY & STABILITY OF BETA-LACTOGLOBULIN The milk protein beta-lactoglobulin (BLg) is concerned with transport of vitamins (esp. retinol) from parent to young offspring. It belongs to a family of proteins with dual molecular recognition properties - for the molecule to be transported and for a receptor cell. One aim of the project is to study complexes of BLg with retinol and related substances by X-ray crystallography and by spectroscopic methods in solution. A second aim is to see whether the thermal stability of the protein is affected by complexing with retinol or other bound molecules. A wide range of techniques will be employed, including X-ray crystallography, spectroscopic methods and molecular modelling by computer graphics and appropriate training will be given. Part of the work will be carried out at the Hannah Laboratory, Ayr. Candidates must have at least a 2(i) degree in Biophysics, Biochemistry, Chemistry or Physics or a related subject. Enquiries please to Professor A C T North, Department of Biophysics, University of Leeds, Leeds LS2 9JT (Leeds (0532) 333023). Email ACTN@uk.ac.leeds.biovax.