Relay-Version: version B 2.10 5/3/83; site utzoo.UUCP Posting-Version: version B 2.10 5/3/83; site cepu.UUCP Path: utzoo!watmath!clyde!akgua!mcnc!decvax!ittvax!dcdwest!sdcsvax!bmcg!cepu!scw From: scw@cepu.UUCP Newsgroups: net.med Subject: Re: Thalidomide Message-ID: <191@cepu.UUCP> Date: Mon, 27-Feb-84 13:56:44 EST Article-I.D.: cepu.191 Posted: Mon Feb 27 13:56:44 1984 Date-Received: Wed, 29-Feb-84 08:33:11 EST References: <2201@phs.UUCP> Organization: VA Wadsworth Med. Center, LA CA Lines: 13 I was under the impression that the problem arose because of the very narrow time frame in which it could cause the deformations (about 1 week in humans) given the ratio of almost 6 to one in gestation time (and a possible variation in the width of the window of vunerability) it could be that the tests never happened to have exactly the right dosage to cause the problems in rats. Add the activity variable and it starts to show how this could be missed. -- Stephen C. Woods (VA Wadsworth Med Ctr./UCLA Dept. of Neurology) uucp: { {ihnp4, uiucdcs}!bradley, hao, trwrb, sdcsvax!bmcg}!cepu!scw ARPA: cepu!scw@ucla-locus location: N 34 06'37" W 118 25'43"