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From: scw@cepu.UUCP
Newsgroups: net.med
Subject: Re: Thalidomide
Message-ID: <191@cepu.UUCP>
Date: Mon, 27-Feb-84 13:56:44 EST
Article-I.D.: cepu.191
Posted: Mon Feb 27 13:56:44 1984
Date-Received: Wed, 29-Feb-84 08:33:11 EST
References: <2201@phs.UUCP>
Organization: VA Wadsworth Med. Center, LA CA
Lines: 13

I was under the impression that the problem arose because of the very
narrow time frame in which it could cause the deformations (about 1
week in humans) given the ratio of almost 6 to one in gestation time
(and a possible variation in the width of the window of vunerability
) it could be that the
tests never happened to have exactly the right dosage to cause the
problems in rats.  Add the activity variable and it starts to show how
this could be missed.
-- 
Stephen C. Woods (VA Wadsworth Med Ctr./UCLA Dept. of Neurology)
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